Effects of arsenic and GSPE on inflammatory cytokines expression in lung tissue induced by arsenic in mice. Mice were exposed to As2O3 (4 mg/kg) (n = 10); 400 mg/kg GSPE was used to antagonize the effects of arsenic. Levels of IL-1β (a), IL-6 (b), IL-10 (c), TNF-α (d), and CRP (e), respectively. Values are expressed as means ± SD. aP < 0.05, compared with the blank control group; bP < 0.05, compared with the arsenic group. (A color version of this figure is available in the online journal.)
GSPE: grape seed proanthocyanidin extract.