Genomic organization of intact cps loci for N. meningitidis global isolates. Arrows indicate the transcriptional orientation of each gene. Insertion sequence (IS) elements are depicted as black triangles (IS1301), horizontal rectangles (ISNme1), and vertical rectangles (IS1016). IS elements are found in serogroup B, C, X, and Y isolates (n = 124 of a total of 422 isolates serogroupable by WGS).