TABLE 4.
Sensitivity, specificity, positive predictive value, and negative predictive value of FP-VLP-MAC-ELISA and NS1-MAC-ELISA for the validation serum panel based on the developed algorithma
| Assay | Disease status | Disease prevalence | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|---|---|
| FP-VLP-MAC-ELISA | ZIKV | 33.30 (21.7–46.7) | 100 (83.2–100) | 80 (64.4–91.0) | 71.40 (57.4–82.3) | 100 |
| DENV | 75 (50.9–91.3) | 92.50 (79.6–98.4) | 83.30 (62.1–93.9) | 88.10 (77.5–94.1) | ||
| NS1-MAC-ELISA | ZIKV | 33.30 (21.7–46.7) | 80 (56.3–94.3) | 95 (83.1–99.4) | 88.90 (67.1–96.9) | 90.50 (79.8–95.8) |
| DENV | 100 (83.2–100) | 92.50 (79.6–98.4) | 87.00 (69.2–95.2) | 100 |
a
PPV, positive predictive value; NPV, negative predictive value. Values are percentages, with 95% confidence intervals given in parentheses.