Table III.
Univariate analyses to detect baseline factors associated with weight change of ≥ 2 kg in subjects treated with acarbose
| Parameter | Univariate analysis | |
|---|---|---|
| OR (95% CI) | P-value | |
| Gender (ref = female) | 0.63 (0.4–0.98) | 0.042* |
| Age [years] | 1.02 (0.99–1.04) | 0.151 |
| Waist circumference [cm] | 1.004 (0.98–1.03) | 0.748 |
| 1-day energy intake from carbohydrates [cal] | 0.998 (0.996–1.001) | 0.258 |
| 1-day energy intake from non-carbohydrates [cal] | 0.997 (0.992–1.001) | 0.146 |
| Total cholesterol [mmol/l] | 1.1 (0.9–1.35) | 0.334 |
| LDL cholesterol [mmol/l] | 1.02 (0.8–1.3) | 0.895 |
| HDL cholesterol [mmol/l] | 0.97 (0.45–2.08) | 0.931 |
| Triglycerides [mmol/l] | 1.04 (0.94–1.14) | 0.475 |
| HbA1c (%): | ||
| Baseline | 0.76 (0.63–0.92) | 0.004* |
| Difference between 24 weeks and baseline | 0.99 (0.83–1.18) | 0.934 |
| Difference between 48 weeks and baseline | 0.9 (0.75–1.07) | 0.229 |
| FPG [mmol/l]: | ||
| Baseline | 0.92 (0.76–1.1) | 0.349 |
| Difference between 24 weeks and baseline | 0.84 (0.72–0.99) | 0.034* |
| Difference between 48 weeks and baseline | 0.7 (0.59–0.82) | < 0.001* |
| 2h-PPG [mmol/l]: | ||
| Baseline | 0.95 (0.88–1.03) | 0.22 |
| Difference between 24 weeks and baseline | 0.9 (0.83–0.97) | 0.005* |
| Difference between 48 weeks and baseline | 0.88 (0.82–0.94) | < 0.001* |
| HOMA-B: | ||
| Baseline | 1.001 (0.9976–1.004) | 0.579 |
| Difference between 24 weeks and baseline | 0.9998 (0.998–1.001) | 0.809 |
| Difference between 48 weeks and baseline | 1.001 (0.999–1.003) | 0.514 |
| HOMA-IR: | ||
| Baseline | 1.01 (0.95–1.07) | 0.71 |
| Difference between 24 weeks and baseline | 0.95 (0.89–1.01) | 0.099 |
| Difference between 48 weeks and baseline | 0.94 (0.88–0.996) | 0.038* |
| Early insulin secretion index: | ||
| Baseline | 1.02 (0.99–1.06) | 0.134 |
| Difference between 24 weeks and baseline | 0.997 (0.98–1.01) | 0.666 |
| Difference between 48 weeks and baseline | 1.002 (0.99–1.01) | 0.654 |
| Whole body insulin sensitivity index: | ||
| Baseline | 0.999 (0.92–1.08) | 0.989 |
| Difference between 24 weeks and baseline | 1.08 (1.02–1.14) | 0.009* |
| Difference between 48 weeks and baseline | 1.15 (1.08–1.22) | < 0.001* |
| AUC for serum insulin at baseline [μIU/ml × min]: | ||
| Baseline | 1.0001 (0.99997–1.0002) | 0.163 |
| Difference between 24 weeks and baseline | 0.9999 (0.9998–1.00002) | 0.12 |
| Difference between 48 weeks and baseline | 0.9998 (0.9997–0.9999) | < 0.001* |
| AUC for glucagon [pg/ml × min]: | ||
| Baseline | 1.00005 (1.00001–1.00009) | 0.019* |
| Difference between 24 weeks and baseline | 0.99997 (0.9999–1.00001) | 0.115 |
| Difference between 48 weeks and baseline | 0.99996 (0.9999–0.999999) | 0.047* |
| AUC for plasma GLP-1 [pmol × min]: | ||
| Baseline | 0.9999 (0.9998–0.999995) | 0.041* |
| Difference between 24 weeks and baseline | 1.0001 (0.99999–1.0002) | 0.103 |
| Difference between 48 weeks and baseline | 1.00005 (0.99995–1.0001) | 0.326 |
FPG – fasting plasma glucose, 2h-PPG – 2 h postprandial glucose.
*
P < 0.05, significantly associated with considerable weight change.