Table IV.
Multivariate analyses to detect factors associated with weight change of ≥ 2 kg in subjects treated with acarbose
| Variable | Multivariate analysis | |
|---|---|---|
| OR (95% CI) | P-value | |
| For baseline variables: | ||
| Gender (ref = female) | 0.58 (0.37–0.93) | 0.025* |
| HbA1c (%) | 0.77 (0.63–0.95) | 0.012* |
| AUC for glucagon [pg/ml × min] | 1.00006 (1.00001–1.0001) | 0.010* |
| AUC for plasma GLP-1 [pmol × min] | 0.9999 (0.9998–1.00004) | 0.230 |
| For differences at 24 weeks: | ||
| ΔFPG between 24 weeks and baseline | 0.89 (0.75–1.05) | 0.170 |
| ΔPPG between 24 weeks and baseline | 0.92 (0.84–1.01) | 0.072 |
| ΔWhole body insulin sensitivity index between 24 weeks and baseline | 1.06 (0.999–1.12) | 0.056 |
| For differences at 48 weeks: | ||
| ΔFPG between 48 weeks and baseline | 0.67 (0.54–0.83) | 0.0002* |
| ΔPPG between 48 weeks and baseline | 0.95 (0.86–1.05) | 0.323 |
| ΔHOMA-IR between 48 weeks and baseline | 1.01 (0.93–1.11) | 0.754 |
| ΔWhole body insulin sensitivity index between 48 weeks and baseline | 1.06 (0.98–1.14) | 0.151 |
| ΔAUC for serum insulin between 48 weeks and baseline | 0.9998 (0.9997–0.99995) | 0.008* |
| ΔAUC for glucagon between 48 weeks and baseline | 0.99998 (0.9999–1.00002) | 0.250 |
Baseline factors and the changes from baseline at week 24 and week 48 were separated into different models. FPG – fasting plasma glucose, 2h-PPG – 2 h postprandial glucose.
*
P < 0.05, significantly associated with considerable weight change.