Table V.
Univariate analyses to detect the baseline factors associated with weight change of ≥ 2 kg in subjects treated with metformin
| Variable | Univariate analysis | |
|---|---|---|
| OR (95% CI) | P-value | |
| Gender (ref = female) | 0.73 (0.47–1.15) | 0.176 |
| Age [years] | 1.02 (0.995–1.04) | 0.127 |
| Waist circumference [cm] | 1.01 (0.98–1.04) | 0.472 |
| 1-day energy intake from carbohydrates [cal] | 1.0004 (0.9974–1.0034) | 0.794 |
| 1-day energy intake from non-carbohydrates [cal] | 0.997 (0.99–1.002) | 0.269 |
| Total cholesterol [mmol/l] | 1.01 (0.84–1.23) | 0.908 |
| LDL cholesterol [mmol/l] | 0.96 (0.76–1.21) | 0.717 |
| HDL cholesterol [mmol/l] | 1.14 (0.57–2.27) | 0.716 |
| Triglycerides [mmol/l] | 0.99 (0.89–1.11) | 0.887 |
| HbA1c (%): | ||
| Baseline | 0.77 (0.64–0.92) | 0.005* |
| Difference between 24 weeks and baseline | 1.08 (0.9–1.31) | 0.396 |
| Difference between 48 weeks and baseline | 0.96 (0.81–1.14) | 0.666 |
| FPG [mmol/l]: | ||
| Baseline | 0.94 (0.77–1.14) | 0.522 |
| Difference between 24 weeks and baseline | 0.91 (0.77–1.08) | 0.284 |
| Difference between 48 weeks and baseline | 0.83 (0.72–0.97) | 0.016* |
| 2h-PPG [mmol/l]: | ||
| Baseline | 0.93 (0.86–0.996) | 0.039* |
| Difference between 24 weeks and baseline | 0.94 (0.88–1.01) | 0.113 |
| Difference between 48 weeks and baseline | 0.94 (0.88–1.004) | 0.063 |
| HOMA-B: | ||
| Baseline | 1.006 (0.9997–1.012) | 0.061 |
| Difference between 24 weeks and baseline | 0.999 (0.99–1.003) | 0.531 |
| Difference between 48 weeks and baseline | 0.999 (0.997–1.002) | 0.678 |
| HOMA-IR: | ||
| Baseline | 0.999 (0.94–1.06) | 0.965 |
| Difference between 24 weeks and baseline | 0.99 (0.93–1.05) | 0.740 |
| Difference between 48 weeks and baseline | 0.97 (0.92–1.02) | 0.193 |
| Early insulin secretion index: | ||
| Baseline | 0.99 (0.97–1.01) | 0.322 |
| Difference between 24 weeks and baseline | 1.01 (0.99–1.02) | 0.502 |
| Difference between 48 weeks and baseline | 1.01 (0.99–1.04) | 0.166 |
| Whole body insulin sensitivity index: | ||
| Baseline | 0.97 (0.9–1.06) | 0.49 |
| Difference between 24 weeks and baseline | 1.05 (0.995–1.12) | 0.075 |
| Difference between 48 weeks and baseline | 1.12 (1.05–1.18) | < 0.001* |
| AUC for serum insulin [μIU/ml × min]: | ||
| Baseline | 1.0001 (0.99998–1.0002) | 0.138 |
| Difference between 24 weeks and baseline | 0.9999 (0.9998–1.000001) | 0.052 |
| Difference between 48 weeks and baseline | 0.9999 (0.9998–0.9999998) | 0.0497* |
| AUC for glucagon [pg/ml × min]: | ||
| Baseline | 0.99996 (0.99992–1.000002) | 0.062 |
| Difference between 24 weeks and baseline | 0.99998 (0.9999–1.00002) | 0.406 |
| Difference between 48 weeks and baseline | 0.99998 (0.9999–1.00002) | 0.382 |
| AUC for plasma GLP-1 [pmol × min]: | ||
| Baseline | 1.00002 (0.99991–1.0001) | 0.779 |
| Difference between 24 weeks and baseline | 0.99997 (0.9999–1.0001) | 0.528 |
| Difference between 48 weeks and baseline | 0.99999 (0.9999–1.0001) | 0.755 |
FPG – fasting plasma glucose, 2h-PPG – 2 h postprandial glucose
*
p < 0.05, significantly associated with considerable weight change.