Table VI.

Multivariate analyses to detect the factors associated with weight change of ≥ 2 kg in subjects treated with metformin

Variable	Multivariate analysis
	OR (95% CI)	P-value
For baseline variables:
HbA1c (%)	0.80 (0.65–0.99)	0.036*
2h-PPG [mmol/l]	0.96 (0.89–1.04)	0.348
For differences at 48 weeks:
ΔFPG between 48 weeks and baseline	0.90 (0.77–1.06)	0.214
ΔWhole body insulin sensitivity index between 48 weeks and baseline	1.10 (1.02–1.18)	0.014*
ΔAUC for serum insulin between 48 weeks and baseline	0.99999 (0.9999–1.0001)	0.909

Baseline factors and the changes from baseline at week 24 and week 48 were separated into different models. FPG – fasting plasma glucose, 2h-PPG – 2 h postprandial glucose.

^*P < 0.05, significantly associated with considerable weight change.