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. 2019 Jan 31;17(4):2837–2846. doi: 10.3892/etm.2019.7226

Figure 5.

Figure 5.

(A and B) HeLa cells were transfected with HPV18 E6 siRNA or NC siRNA, and (A) RT-qPCR and (B) western blot analysis were performed to examine the mRNA and protein expression of TIMP2, respectively. **P<0.01 vs. NC siRNA. (C-E) HeLa cells were co-transfected with HPV18 E6 siRNA and miR-133a mimics, or with HPV18 E6 siRNA and miR-NC. (C) RT-qPCR was performed to examine the expression of miR-130a. (D) RT-qPCR and (E) western blot analysis were applied to examine the mRNA and protein expression of TIMP2, respectively. **P<0.01 vs. HPV18 E6 siRNA+miR-NC. NC, negative control; TIMP, tissue inhibitor of metalloproteinases; miR, microRNA; RT-qPCR, reverse transcription-quantitative polymerase chain reaction; HPV, human papillomavirus; siRNA, small interfering RNA.