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. 2019 Feb 21;17(4):3899–3909. doi: 10.3892/ol.2019.10060

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Copyright: © Huang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — (A and B) Representative image of EWSR1 gene rearrangements. Fluorescence in situ hybridization analysis with a dual-color EWSR1 break-apart probe showed that the analyzed tumor cell presented with at least one fusion signal, and the separated red and green signals (arrowhead), indicative of a rearrangement of one copy of EWSR1. Scale bars, 5 µm. (C and D) Ultrastructural features, including some isolated dense-core secretory granules (arrowhead), irregularly shaped nuclei and prominent nucleoli, were identified. Scale bars, (C) 5 µm and (D) 2 µm. EWSR1, Ewing sarcoma breakpoint region 1.