Table 2.
Top 10 of VHDJH rearrangement patterns in colon cancer and normal epithelial cells
|
Cancer |
Normal |
|||||||
| V | D | J | % | V | D | J | % | |
| Patient-1 | hIGHV3-13 | hIGHD3-9 | hIGHJ6 | 66.84% | hIGHV1-8 | hIGHD7-27 | hIGHJ4 | 27.25% |
| hIGHV3-30 | hIGHD6-19 | hIGHJ6 | 15.81% | hIGHV3-74 | hIGHD6-19 | hIGHJ4 | 24.71% | |
| hIGHV3-30-3 | hIGHD2-8 | hIGHJ4 | 4.90% | hIGHV3-23 | hIGHD2-21 | hIGHJ5 | 18.58% | |
| hIGHV5-51 | hIGHD3-16 | hIGHJ4 | 3.69% | hIGHV1-8 | hIGHD1-7 | hIGHJ3 | 6.31% | |
| hIGHV3-23 | hIGHD6-13 | hIGHJ4 | 3.58% | hIGHV5-51 | hIGHD3-16 | hIGHJ4 | 5.00% | |
| hIGHV3-7 | hIGHD3-9 | hIGHJ6 | 1.00% | hIGHV3-23 | hIGHD3-22 | hIGHJ6 | 2.92% | |
| hIGHV3-33 | hIGHD6-19 | hIGHJ6 | 0.79% | hIGHV3-74 | hIGHD4-17 | hIGHJ4 | 2.20% | |
| hIGHV3-13 | hIGHD6-13 | hIGHJ6 | 0.53% | hIGHV3-21 | hIGHD2-15 | hIGHJ5 | 1.19% | |
| hIGHV3-30 | hIGHD2-8 | hIGHJ4 | 0.37% | hIGHV3-74 | hIGHD2-21 | hIGHJ5 | 1.17% | |
| hIGHV3-64 | hIGHD6-19 | hIGHJ6 | 0.26% | hIGHV3-23 | hIGHD6-19 | hIGHJ4 | 1.06% | |
| Patient-2 | hIGHV1-58 | hIGHD3-22 | hIGHJ4 | 43.86% | hIGHV1-18 | hIGHD4-17 | hIGHJ4 | 24.34% |
| hIGHV1-46 | hIGHD3-9 | hIGHJ4 | 18.00% | hIGHV3-11 | hIGHD5-5 | hIGHJ2 | 10.95% | |
| hIGHV3-43 | hIGHD3-22 | hIGHJ4 | 10.20% | hIGHV3-74 | hIGHD6-13 | hIGHJ1 | 10.28% | |
| hIGHV3-23 | hIGHD3-9 | hIGHJ4 | 6.28% | hIGHV3-9 | hIGHD6-19 | hIGHJ4 | 10.02% | |
| hIGHV1-69 | hIGHD4-17 | hIGHJ3 | 5.31% | hIGHV3-23 | hIGHD3-10 | hIGHJ4 | 6.67% | |
| hIGHV1-69 | hIGHD2-15 | hIGHJ5 | 3.98% | hIGHV4-4 | hIGHD3-22 | hIGHJ4 | 5.92% | |
| hIGHV1-2 | hIGHD5-5 | hIGHJ4 | 2.77% | hIGHV3-15 | hIGHD3-10 | hIGHJ4 | 3.87% | |
| hIGHV1-58 | hIGHD5-5 | hIGHJ4 | 1.08% | hIGHV3-49 | hIGHD6-19 | hIGHJ4 | 2.88% | |
| hIGHV3-53 | hIGHD6-6 | hIGHJ4 | 1.01% | hIGHV4-59 | hIGHD3-22 | hIGHJ4 | 2.34% | |
| hIGHV1-3 | hIGHD7-27 | hIGHJ6 | 0.61% | hIGHV3-53 | hIGHD6-19 | hIGHJ4 | 2.14% | |
| Patient-3 | hIGHV3-23 | hIGHD4-4 | hIGHJ5 | 11.63% | hIGHV1-18 | hIGHD4-17 | hIGHJ4 | 24.71% |
| hIGHV7-4-1 | hIGHD1-26 | hIGHJ6 | 11.28% | hIGHV3-9 | hIGHD6-19 | hIGHJ4 | 11.82% | |
| hIGHV3-74 | hIGHD6-6 | hIGHJ5 | 11.16% | hIGHV3-11 | hIGHD5-5 | hIGHJ2 | 10.21% | |
| hIGHV3-23 | hIGHD3-16 | hIGHJ5 | 6.15% | hIGHV3-74 | hIGHD6-13 | hIGHJ1 | 9.42% | |
| hIGHV3-48 | hIGHD4-4 | hIGHJ4 | 5.29% | hIGHV3-23 | hIGHD3-10 | hIGHJ4 | 6.20% | |
| hIGHV2-5 | hIGHD5-12 | hIGHJ4 | 5.16% | hIGHV4-4 | hIGHD3-22 | hIGHJ4 | 5.93% | |
| hIGHV1-69 | hIGHD5-5 | hIGHJ4 | 4.83% | hIGHV3-15 | hIGHD3-10 | hIGHJ4 | 4.39% | |
| hIGHV3-23 | hIGHD3-22 | hIGHJ5 | 4.18% | hIGHV4-59 | hIGHD3-22 | hIGHJ4 | 2.78% | |
| hIGHV3-53 | hIGHD5-12 | hIGHJ4 | 2.14% | hIGHV3-49 | hIGHD6-19 | hIGHJ4 | 2.50% | |
| hIGHV3-11 | hIGHD2-15 | hIGHJ4 | 2.07% | hIGHV3-53 | hIGHD6-19 | hIGHJ4 | 2.06% | |
| Patient-4 | hIGHV3-7 | hIGHD3-22 | hIGHJ5 | 57.78% | hIGHV3-74 | hIGHD2-8 | hIGHJ5 | 88.00% |
| hIGHV3-48 | hIGHD3-22 | hIGHJ5 | 13.33% | hIGHV1-8 | hIGHD7-27 | hIGHJ4 | 4.00% | |
| hIGHV1-58 | hIGHD3-22 | hIGHJ4 | 11.11% | hIGHV3-74 | hIGHD6-19 | hIGHJ4 | 2.00% | |
| hIGHV3-43 | hIGHD3-22 | hIGHJ4 | 6.67% | hIGHV3-74 | hIGHD2-21 | hIGHJ5 | 2.00% | |
| hIGHV3-23 | hIGHD3-9 | hIGHJ4 | 4.44% | hIGHV3-23 | hIGHD2-21 | hIGHJ5 | 2.00% | |
| hIHGV3-74 | hIGHD2-8 | hIGHJ5 | 2.22% | hIGHV3-74 | hIGHD5-5 | hIGHJ6 | 2.00% | |
| hIGHV3-21 | hIGHD3-22 | hIGHJ5 | 2.22% | N/A | ||||
| hIHGV1-46 | - | hIGHJ4 | 2.22% | N/A | ||||
| Patient-5 | hIHGV3-7 | hIHGD3-22 | hIHGJ5 | 65.96% | hIGHV3-7 | hIGHD3-22 | hIGHJ5 | 60.00% |
| hIHGV3-21 | hIHGD3-22 | hIHGJ5 | 4.26% | hIGHV1-8 | hIGHD7-27 | hIGHJ4 | 12.31% | |
| hIHGV3-74 | hIHGD6-6 | hIHGJ5 | 4.26% | hIGHV1-8 | hIGHD1-7 | hIGHJ3 | 6.15% | |
| hIHGV7-4-1 | hIHGD1-26 | hIHGJ6 | 4.26% | hIGHV3-23 | hIGHD2-21 | hIGHJ5 | 4.62% | |
| hIHGV3-48 | hIHGD3-22 | hIHGJ5 | 4.26% | hIGHV3-74 | hIGHD6-19 | hIGHJ4 | 4.62% | |
| hIHGV3-48 | hIHGD4-4 | hIHGJ4 | 4.26% | hIGHV3-74 | hIGHD2-8 | hIGHJ4 | 3.08% | |
| hIHGV3-11 | hIHGD2-15 | hIHGJ4 | 2.13% | hIGHV5-51 | hIGHD3-16 | hIGHJ4 | 1.54% | |
| hIHGV3-33 | hIHGD3-22 | hIHGJ5 | 2.13% | hIGHV3-9 | hIGHD2-21 | hIGHJ5 | 1.54% | |
| hIHGV3-23 | hIHGD3-22 | hIHGJ5 | 2.13% | hIGHV3-33 | hIGHD3-22 | hIGHJ5 | 1.54% | |
| hIHGV3-72 | hIHGD1-7 | hIHGJ6 | 2.13% | hIGHV3-74 | hIGHD6-25 | hIGHJ4 | 1.54% | |
| Patient-6 | hIGHV1-8 | hIGHD6-13 | hIGHJ5 | 44.32% | N/A | |||
| hIGHV4-61 | hIGHD3-16 | hIGHJ6 | 16.60% | |||||
| hIGHV1-8 | hIGHD3-10 | hIGHJ5 | 14.34% | |||||
| hIGHV3-23 | hIGHD3-22 | hIGHJ3 | 11.74% | |||||
| hIGHV1-8 | hIGHD7-27 | hIGHJ4 | 6.00% | |||||
| hIGHV3-23 | hIGHD2-21 | hIGHJ5 | 4.57% | |||||
| hIGHV3-74 | hIGHD6-19 | hIGHJ4 | 0.96% | |||||
| hIGHV4-61 | hIGHD2-21 | hIGHJ6 | 0.17% | |||||
| hIGHV3-74 | hIGHD3-22 | hIGHJ3 | 0.13% | |||||
| hIGHV1-8 | hIGHD3-16 | hIGHJ5 | 0.13% | |||||
| Patient-7 | hIGHV3-7 | hIGHD3-22 | hIGHJ5 | 80.95% | N/A | |||
| hIGHV3-21 | hIGHD3-22 | hIGHJ5 | 1.28% | |||||
| hIGHV3-33 | hIGHD3-22 | hIGHJ5 | 0.92% | |||||
| hIGHV3-23 | hIGHD4-4 | hIGHJ5 | 0.92% | |||||
| hIGHV7-4-1 | hIGHD1-26 | hIGHJ6 | 0.92% | |||||
| hIGHV3-23 | hIGHD3-22 | hIGHJ5 | 0.73% | |||||
| hIGHV3-48 | hIGHD3-22 | hIGHJ5 | 0.73% | |||||
| hIGHV2-5 | hIGHD5-12 | hIGHJ4 | 0.73% | |||||
| hIGHV3-48 | hIGHD4-4 | hIGHJ4 | 0.55% | |||||
| hIGHV3-48 | hIGHD3-22 | hIGHJ5 | 0.55% | |||||