Table 3.
Comparisons of clinical features among different genotypes of the IL-1β gene polymorphisms in COM patients.
| Items | rs16944 | rs1143627 | rs1143634 | rs2853550 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AA | AG | GG | P value | CC | CT | TT | P value | CC | CT | P value | CC | CT | P value | |
| Age Median (IQR) | 42.50 (27.00, 50.00) | 37.50 (24.00, 52.00) | 39.00 (28.50, 48.50) | 0.696 | 42.00 (27.00, 50.00) | 37.50 (24.00, 52.25) | 39.00 (28.50, 48.50) | 0.838 | 39.00 (26.00, 50.00) | 48.50 (39.50, 59.75) | 0.182 | 39.00 (26.00, 50.25) | 38.00 (27.00, 49.00) | 0.769 |
| Sex ratio (M/F) | 28/12 | 100/20 | 57/16 | 0.185 | 30/12 | 98/20 | 57/16 | 0.263 | 182/47 | 3/1 | 1.000 | 163/43 | 22/5 | 0.776 |
| Positive rate of culture (%) (E/T) | 68.97 (20/29) | 65.17 (58/89) | 61.82 (34/55) | 0.803 | 67.74 (21/31) | 65.52 (57/87) | 61.82 (34/55) | 0.839 | 64.91 (111/171) | 50 (1/2) | 1.000 | 62.18 (97/156) | 88.24 (15/17) | 0.033 |
| Polymicrobial infection (%) (E/T) | 30.00 (6/20) | 18.97 (11/58) | 20.59 (7/34) | 0.597 | 28.57 (6/21) | 19.30 (11/57) | 20.59 (7/34) | 0.682 | 21.62 (24/111) | 0 (0/1) | 1.000 | 21.65 (21/97) | 20 (3/15) | 1.000 |
| WBC (×109/L) Median (IQR) |
7.66 (6.33, 9.07) | 7.34 (5.59, 9.36) | 6.93 (6.11, 8.51) | 0.414 | 7.66 (6.38, 9.16) | 7.34 (5.55, 9.28) | 6.93 (6.11, 8.51) | 0.346 | 7.24 (5.94, 8.93) | 7.30 (5.46, 7.90) | 0.660 | 7.25 (6.03, 8.77) | 7.39 (5.41, 9.99) | 0.833 |
| CRP (mg/L) Median (IQR) | 3.99 (1.67, 33.36) | 6.20 (2.28, 21) | 7.65 (2.41, 18.58) | 0.646 | 3.99 (1.48, 29.61) | 6.20 (2.32, 21.20) | 7.65 (2.41, 18.58) | 0.567 | 6.25 (2.24, 19.70) | 6.51 (2.31, 14.18) | 0.844 | 6.57 (2.37, 19.35) | 4.67 (1.57, 17.56) | 0.459 |
| PCT (ng/ml) Median (IQR) | 0.037 (0.020, 0.053) | 0.035 (0.023, 0.069) | 0.038 (0.026, 0.051) | 0.894 | 0.038 (0.020, 0.053) | 0.035 (0.023, 0.070) | 0.038 (0.026, 0.051) | 0.912 | 0.037 (0.023, 0.062) | 0.030 (0.024, 0.038) | 0.499 | 0.037 (0.024, 0.062) | 0.027 (0.020, 0.051) | 0.273 |
| IL-6 (pg/ml) Median (IQR) | 7.98 (3.73, 18.17) | 21.10 (8.71, 74.49) | 12.44 (4.34, 53.46) | 0.005 | 7.98 (3.60, 20.08 | 21.1 (8.84, 74.50) | 12.44 (4.34, 53.46) | 0.003 | 15.39 (6.55, 59.78) | 24.29 (4.05, 38.95) | 0.781 | 14.76 (6.22, 59.35) | 24.67 (8.10, 77.43) | 0.379 |
| TNF-α (pg/ml) Median (IQR) | 9.67 (7.67, 11.20) | 9.78 (7.56, 13.05) | 8.73 (7.21, 11.53) | 0.494 | 9.7 (8.04, 11.60) | 9.42 (7.55, 13.10) | 8.73 (7.21, 11.53) | 0.510 | 9.26 (7.38, 12.00) | 9.04 (8.07, 12.77) | 0.872 | 9.16 (7.50, 12.00) | 10.40 (6.65, 13.50) | 0.698 |
| SAA (mg/L) Median (IQR) | 7.40 (2.45, 28.25) | 9.40 (4.20, 37.40) | 5.00 (3.23, 61.75) | 0.776 | 8.15 (2.48, 26.58) | 8.55 (4.18, 37.53) | 5.00 (3.23, 61.75) | 0.861 | 7.60 (3.30, 29.05) | 272.30 | 0.135 | 8.30 (3.33, 30.33) | 5.25 (2.85, 222.05) | 0.858 |
COM: chronic osteomyelitis; IQR: interquartile range; M/F: male/female; E/T: events/total; WBC: white blood cell count; CRP: C-reactive protein; PCT: procalcitonin; IL-6: interleukin-6; TNF-a: tumor necrosis factor-a; SAA: serum amyloid A.