Table I.

GO analysis of the DEGs regulated by ENO1 silencing.

Identifier	Functional term	Count	P-value
Biological process
GO:0006350	Transcription	86	6.43×10−7
GO:0006355	Regulation of transcription, DNA-dependent	73	5.37×10−6
GO:0045449	Regulation of transcription	96	1.08×10−5
GO:0051252	Regulation of RNA metabolic process	73	1.18×10−5
GO:0010629	Negative regulation of gene expression	28	1.00×10−4
GO:0016481	Negative regulation of transcription	26	1.40×10−4
GO:0006357	Regulation of transcription from RNA polymerase II promoter	35	1.81×10−4
GO:0048514	Blood vessel morphogenesis	16	1.98×10−4
GO:0010605	Negative regulation of macromolecule metabolic process	35	2.17×10−4
GO:0045934	Negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	27	3.13×10−4
GO:0010558	Negative regulation of macromolecule biosynthetic process	28	3.74×10−4
GO:0051172	Negative regulation of nitrogen compound metabolic process	27	3.82×10−4
GO:0045892	Negative regulation of transcription, DNA-dependent	21	4.39×10−4
GO:0051253	Negative regulation of RNA metabolic process	21	5.34×10−4
GO:0031327	Negative regulation of cellular biosynthetic process	28	5.50×10−4
GO:0009890	Negative regulation of biosynthetic process	28	7.64×10−4
GO:0001568	Blood vessel development	16	9.55×10−4
GO:0001525	Angiogenesis	12	9.60×10−4
GO:0007049	Cell cycle	34	1.189962×10−3
GO:0001944	Vasculature development	16	1.215671×10−3
GO:0031099	Regeneration	8	1.374438×10−3
GO:0051726	Regulation of cell cycle	18	3.03174×10−3
GO:0031100	Organ regeneration	5	3.326962×10−3
GO:0007507	Heart development	13	6.280962×10−3
GO:0030593	Neutrophil chemotaxis	4	8.795164×10−3
GO:0007167	Enzyme-linked receptor protein signaling pathway	17	9.52888×10−3
Cell component
GO:0031981	Nuclear lumen	52	2.58×10−4
GO:0070013	Intracellular organelle lumen	60	3.75×10−4
GO:0043233	Organelle lumen	60	6.74×10−4
GO:0031974	Membrane-enclosed lumen	60	1.097428×10−3
GO:0005654	Nucleoplasm	34	1.312471×10−3
GO:0005783	Endoplasmic reticulum	34	4.951755×10−3
GO:0044451	Nucleoplasm part	22	8.735324×10−3
Molecular function
GO:0003700	Transcription factor activity	43	2.18×10−4
GO:0030528	Transcription regulator activity	58	5.22×10−4
GO:0008092	Cytoskeletal protein binding	26	6.25×10−4
GO:0016564	Transcription repressor activity	18	1.995073×10−3
GO:0043014	α-tubulin binding	4	2.056678×10−3
GO:0003677	DNA binding	77	3.813995×10−3
GO:0046914	Transition metal ion binding	88	6.180415×10−3
GO:0003779	Actin binding	17	6.453361×10−3
GO:0008270	Zinc ion binding	75	6.826083×10−3
GO:0004672	Protein kinase activity	26	7.297114×10−3

GO, Gene Ontology.