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. Author manuscript; available in PMC: 2019 Mar 20.
Published in final edited form as: J Alzheimers Dis. 2019;67(1):393–410. doi: 10.3233/JAD-180941

Figure 2. HDL mixed with apoB, but not HDL mixed with apoE3, increased Aβ.

Figure 2.

(A) In SH-SY5Y cells expressing wild-type AβPP, treatment with HDL (50 μg/ml) mixed with apoB (20 μg/ml) for 3 days significantly increased secreted levels Aβ1–40 and Aβ1–42. Treatment with HDL (50 μg/ml) mixed with apoE3 (20 μg/ml) for 3 days did not significantly increase secreted levels of Aβ (n=5). (B) In SH-SY5Y cells expressing wild-type AβPP, treatment with HDL (50 μg/ml) mixed with apoB (20 μg/ml) for 3 days significantly increased intraneuronal levels of Aβ1–40 and Aβ1–42. Treatment with HDL (50 μg/ml) mixed with apoE3 (20 μg/ml) for 3 days did not significantly increase intraneuronal levels of Aβ (n=5).