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. Author manuscript; available in PMC: 2019 Mar 20.
Published in final edited form as: J Alzheimers Dis. 2019;67(1):393–410. doi: 10.3233/JAD-180941

Figure 3. LDL, but not HDL, de-acidified endolysosomes.

Figure 3.

(A) In SH-SY5Y cells expressing wild-type AβPP, LDL (50 μg/ml for 3 days), but not HDL (50 μg/ml for 3 days), significantly elevated endolysosome pH (***p<0.001, n=16–20 cells from 4 different plates). (B) LDL, but not HDL, significantly decreased protein levels of V1A1 and V0a1 subunits of v-ATPase in total cell lysates of SH-SY5Y cells (*p<0.05, **p<0.01, n=4). (C) LDL, but not HDL, significantly decreased protein levels of v-ATPase V1A1 and V0a1 subunits in enriched lysosome fractions of SH-SY5Y cells (**p<0.01, n=4).