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. Author manuscript; available in PMC: 2019 Mar 20.
Published in final edited form as: J Alzheimers Dis. 2019;67(1):393–410. doi: 10.3233/JAD-180941

Figure 7. TRPML1 knockdown potentiated LDL-induced increases in Aβ.

Figure 7.

(A) LDL (50 μg/ml for 3 days) significantly decreased protein levels of TRPML1 in primary cultured rat cortical neurons (n=4). (B) TRPML1 knockdown, per se, did not affect secreted Aβ levels. However, TRPML1 knockdown significantly exacerbated LDL-induced increases in Aβ levels in primary cultured rat cortical neurons (n=4).