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. Author manuscript; available in PMC: 2019 Aug 17.
Published in final edited form as: ACS Chem Biol. 2018 Jun 15;13(8):2048–2057. doi: 10.1021/acschembio.8b00251

Figure 4. Potential GLUT antagonists display differential effects on GBM PDX cells and NHAs.

Figure 4.

Cell growth of D456 GBM PDX and NHA cells following treatment with (a) SRI-37683 (**p < 0.001 one-ay ANOVA and Dunnett’s multiple comparisons between D456 and NHA treated with 5 μM and 20 μM) (b) SRI-37684 (**p < 0.001 one-ay ANOVA and Dunnett’s multiple comparisons between D456 and NHA treated with 5 μM) (c) SRI- 37218 (**p < 0.005 one-ay ANOVA and Dunnett’s multiple comparisons between D456 and NHA treated with 50 μM) (d) SRI-39260 (e) SRI-39256 (f) SRI-39257 at indicated concentrations for 7 days (g) Representative images of D456 GBM PDX cells on day 7 after treatment with indicated concentrations of antagonists. (Representative data from 3 experiments with n=3 per group)