Table I.
Summary of cohort characteristics stratified by COP-MPV.
| Variable | COP-MPV 0a | COP-MPV 1a | COP-MPV 2a | P-value |
|---|---|---|---|---|
| Age (years) | 66.48 | 63.23 | 64.048 | 0.6027 |
| Sex | ||||
| Male | 20 | 43 | 13 | 0.6444 |
| Female | 7 | 22 | 8 | |
| BMI (kg/m2) | 24.89 | 26.50 | 28.76 | 0.0655 |
| History of alcohol use | ||||
| Yes | 12 | 33 | 12 | 0.6810 |
| No | 15 | 32 | 9 | |
| History of smoking | ||||
| Yes | 13 | 31 | 12 | 0.7426 |
| No | 14 | 34 | 9 | |
| ECOG score | ||||
| 0 | 16 | 50 | 16 | 0.3801 |
| 1 | 9 | 14 | 4 | |
| 2 | 2 | 1 | 1 | |
| Tumor primary location | ||||
| Nasopharynx | 0 | 1 | 0 | 0.2692 |
| Oropharynx | 5 | 13 | 2 | |
| Oral cavity | 8 | 29 | 15 | |
| Larynx | 4 | 6 | 0 | |
| Salivary gland | 3 | 7 | 2 | |
| Paranasal sinus | 2 | 5 | 0 | |
| Cervical lymph node or unknown primary | 2 | 1 | ||
| Cutaneous | 3 | 3 | 0 | |
| Tumor histology | ||||
| Adenocarcinoma | 1 | 5 | 0 | 0.6290 |
| Squamous cell carcinoma | 21 | 52 | 20 | |
| Adenoid cystic carcinoma | 1 | 1 | 0 | |
| Mucoepidermoid carcinoma | 1 | 1 | 0 | |
| Basal cell carcinoma | 1 | 0 | 0 | |
| Other | 2 | 6 | 1 | |
| Tumor differentiation | ||||
| Unable to assess | 7 | 5 | 4 | 0.0617 |
| Well differentiated | 7 | 10 | 3 | |
| Moderate differentiation | 11 | 29 | 10 | |
| Poor differentiation | 2 | 21 | 4 | |
| Staging pT | ||||
| pT0 | 2 | 2 | 2 | 0.6384 |
| pT1 | 10 | 25 | 9 | |
| pT2 | 11 | 19 | 6 | |
| pT3 | 3 | 11 | 1 | |
| pT4 | 1 | 8 | 3 | |
| Staging pN | ||||
| pN0 | 19 | 41 | 16 | 0.8009 |
| pN1 | 3 | 10 | 2 | |
| pN2 | 3 | 7 | 3 | |
| pN3 | 2 | 6 | 0 | |
| Adjuvant radiotherapy | ||||
| Yes | 12 | 27 | 4 | 0.1339 |
| No | 15 | 38 | 17 | |
| Adjuvant chemoradiotherapy | ||||
| Yes | 6 | 14 | 2 | 0.4420 |
| No | 21 | 51 | 19 | |
| Surgical margin status | ||||
| Positive | 3 | 9 | 3 | 0.9292 |
| Negative | 24 | 56 | 18 | |
| WBC (109/l) | 6.51 | 7.56 | 9.16 | 0.0036b |
| Hemoglobin (g/dl) | 13.39 | 13.30 | 6.81 | 0.1356 |
| MPV (fl) | 9.66 | 9.81 | 11.25 | <0.0001b |
| Platelet Count (109/l) | 178.33 | 249.88 | 275.14 | <0.0001b |
a
Continuous variables presented as mean values and categorical variables are represented as integers
b
Statistically significant at P<0.05. BMI, body-mass index; ACE-27, adult comorbidity evaluation 27 score; ECOG, Eastern Cooperative Oncology Group score; WBC, white blood cell count; MPV, mean platelet volume; COP-MPV, combination of platelet count and mean platelet volume score.