Table II.
Multivariate Cox Regression Analysis of Event-Free Survival.
| Multivariate analysis | |||
|---|---|---|---|
| Variable | HR | 95% CI | P-value |
| Age | Nsa | – | – |
| Sex | |||
| Male | Reference | ||
| Female | Nsa | – | – |
| BMI | Nsa | – | – |
| History of alcohol use | Nsa | – | – |
| History of smoking | Nsa | – | – |
| Overall ACE-27 score | Nsa | – | – |
| ECOG score | Nsa | – | – |
| Karnofsky score | |||
| 100 | Reference | ||
| 90 | Nsa | – | – |
| 80 | Nsa | – | – |
| ≤70 | c | – | – |
| Tumor primary location | Nsa | – | – |
| Tumor differentiation | |||
| Well differentiated | Reference | ||
| Moderately differentiated | 2.37 | 1.17–4.84 | 0.0171b |
| Poorly differentiated | Nsa | – | – |
| Staging pT | |||
| pT1 | Reference | ||
| pT2 | Nsa | – | – |
| pT3 | 8.91 | 3.46–22.91 | <0.0001b |
| pT4 | Nsa | – | – |
| Staging pN | |||
| pN0 | Reference | ||
| pN1 | 3.41 | 1.11–10.47 | 0.0321b |
| pN2 | 3.30 | 1.23–8.86 | 0.0177b |
| pN3 | c | ||
| Adjuvant radiotherapy | Nsa | – | – |
| Adjuvant chemoradiotherapy | Nsa | – | – |
| Surgical margin status | 3.77 | 1.54–9.24 | 0.0037b |
| WBC | Nsa | – | – |
| Hemoglobin | 0.62 | 0.50–0.78 | <0.0001b |
| MPV | 2.16 | 0.95–4.92 | 0.0659 |
| Platelet count | Nsa | – | – |
| COP-MPV | |||
| 0 | Reference | ||
| 1 | Nsa | – | – |
| 2 | Nsa | – | – |
a
P>0.1, thus these were removed from the multivariate regression model via backwards selection
b
Statistically significant (P<0.05)
c
Small numbers in variable and so were ineligible for multivariate model analysis. 95% CI, 95% confidence interval; HR, hazard ratio; BMI, body-mass index; ACE-27, adult comorbidity evaluation 27 score; ECOG, eastern cooperative oncology group score; WBC, white blood cell count; MPV, mean platelet volume; COP-MPV, combination of platelet count and mean platelet volume score; Ns, not significant.