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. 2019 Feb 13;3(4):716–733. doi: 10.1210/js.2018-00228

Figure 8.

Figure 8.

GnRH-Bmal1−/− and Kiss-Bmal1−/− produce an LH surge at lights off and have normal GnRH and kiss-10 LH responsiveness. (A) LH levels at lights off in an induced surge paradigm (for nonsurging example, please see Fig. 1A) (n = 5 to 9, one-way ANOVA not significant). (B) LH levels before and 10 min after 1 μg/kg GnRH administration (n = 3 to 9; two-way ANOVA significant for time; F1,30 = 56.89, P < 0.0001; Sidak multiple comparisons test). (C) LH levels before and 10 min after 30 nmol of kiss-10 administration (n = 3 to 8; two-way ANOVA significant for time; F1,28 = 43.61, P < 0.0001; Sidak multiple comparisons test). Different letters indicate significantly different groups (P < 0.05).