Table 3.
Summary of Cartilage Concentrations of Fluticasone Propionate.a
| Cartilage Concentration of Fluticasone Proprionate (ng/mL) |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| n | Mean | Gmean | SD | CV (%) | Min | Q1 | Median | Q3 | Max | |
| 0.6 mg EP-104IAR | ||||||||||
| Day 7 | 4 | 45.4 | 8.0 | 79.3 | 234 | 0.8 | 1.8 | 8.4 | 52.0 | 164.0 |
| Day 29 | 4 | 1.0 | 0.4 | 1.2 | 167 | 0.1 | 0.2 | 0.6 | 1.5 | 2.7 |
| Day 46 | 4 | 0.2 | 0.1 | 0.1 | 97 | 0.0 | 0.1 | 0.1 | 0.2 | 0.3 |
| Day 60 | 4 | 1.3 | 0.4 | 2.2 | 180 | 0.1 | 0.1 | 0.3 | 1.5 | 4.6 |
| 12 mg EP-104IAR | ||||||||||
| Day 7 | 4 | 413.9 | 198.9 | 349.1 | 186 | 13.7 | 175.2 | 464.5 | 703.2 | 713.0 |
| Day 29 | 4 | 52.2 | 8.7 | 61.1 | 296 | 0.3 | 1.6 | 42.7 | 93.2 | 123.0 |
| Day 46 | 4 | 2.7 | 2.0 | 2.6 | 89 | 0.8 | 1.3 | 1.7 | 3.1 | 6.5 |
| Day 60 | 4 | 84.7 | 53.9 | 103.0 | 100 | 26.5 | 33.3 | 36.5 | 87.9 | 239.0 |
CV = coefficient of variation; Q1 = first quartile; Q3 = third quartile.
a
The lower limit of quantitation of the assay was 100 pg/mL; all values below this level have been reported at their assayed value.