Fig. 3.

Altered PGE2-EP2 expression is associated with disease severity in ACLF. a EP2 expression on CD8⁺ T cells in ACLF (n = 19) and ACLF-MOF (n = 11) was determined by flow cytometry. ACLF-MOF was defined as the development of multi-organ failure within the 90-day follow-up. b Plasma PGE2 levels were measured in survivors (n = 20) and the death group (n = 10) during the 30-day follow-up by ELISA. c Correlation analysis between EP2 expression and the prognostic score. d Correlation analysis between EP2 expression and the plasma cytokine level. The horizontal line represented the median. Statistical analyses were analyzed using the Mann–Whitney test or spearman correlation. *p < 0.05