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. 2019 Mar 20;19:65. doi: 10.1186/s12935-019-0774-5

Table 3.

Nucleotide sequence variations in the LCR of HPV16 (n = 95)

n = 95 LCR base sites
HPV16: T A A C A A C A C T A T T G T
7 7 7 7 7 7 7 7 7 7 7 7 7 7 7
1 2 2 2 2 2 3 3 3 4 4 4 4 6 7
Variants: 9 3 5 6 8 8 0 2 9 0 1 3 4 9 1
9 1 3 8 5 7 8 3 3 4 7 8 7 9 1
C C G T C C T C T G G G C A G
E reference: T A A C A A C A C T A T T G T
AA: T C A C A A C A T T A T T G T
As: C C A T C C C A C T A T T G T
Af: T A A C A A C A C T A T T G T
Mutation: 16 2 1 16 16 11 1 1 1 1 9 1 39 3 16
Ep-350T 16
Ep-350T 2
Ep 2
Ep 1
Ep 1 C
Ep 1 C T T
Ep 1
E-T7711G 15 G
E-T7711G 1 G G
E-T7447C 27 C
E-T7447C 7 C
E-T7447C 3 C A
E-T7447C 1 C
E-T7447C 1 C
As 9 C T C C G
As 2 C T C
As 2 C T C
As 1 C T C C C
As 1 C G T C C
As 1 C T C G
n = 95 LCR base sites
HPV16: A T G G T G C G G A
7 7 7 7 7 7 7 7 7 7 C C A C
7 7 7 8 8 8 8 8 8 8 1 2 4 7
Variants: 2 7 9 0 2 3 3 3 6 7 3 4 1 3
7 8 6 3 4 1 7 9 6 1 T T C T
C C A A C C T A A G
E reference: A T G G T G C G G A C C A C
AA: A T G G T G C G G A C C A C
As: C C G G T G C A G A C T A C
Af: A T G G T T C G A A C C A C
Mutation: 16 1 3 1 3 1 1 16 7 2 3 16 2 2
Ep-350T 16
Ep-350T 2 T
Ep 2 C T C
Ep 1 C
Ep 1
Ep 1
Ep 1 C
E-T7711G 15
E-T7711G 1
E-T7447C 27
E-T7447C 7 A
E-T7447C 3 A
E-T7447C 1 A
E-T7447C 1 T
As 9 C A T
As 2 C A G T
As 2 C A T
As 1 C T A T
As 1 C C A T
As 1 C A T

Bolditalic are the most common mutation sites

Ep European prototype, AA Asian American lineage, As Asia lineage, Af African lineage