Table 3.
AUCs by subgroups
| BCRATa | Gailb | Gail + AMHb | Gail + testosteroneb | Gail + AMH + testosteroneb | |
|---|---|---|---|---|---|
| Total AUC | 55.0 (53.1, 56.8) | 55.3 (53.4, 57.1) | 57.6 (55.7, 59.5) | 56.2 (54.4, 58.1) | 58.1 (56.2, 59.9) |
| Age at blood donation, years | |||||
| ≤ 40 | 55.9 (52.3, 59.6) | 56.2 (52.5, 59.8) | 57.5 (53.8, 61.1) | 57.3 (53.7, 61.0) | 58.1 (54.4, 61.8) |
| 41–45 | 55.2 (52.2, 58.2) | 54.9 (51.9, 57.9) | 56.3 (53.3, 59.2) | 56.0 (53.0, 58.9) | 56.6 (53.7, 59.6) |
| > 45 | 58.6 (55.4, 61.9) | 58.6 (55.3, 61.9) | 60.6 (57.4, 63.8) | 60.9 (57.7, 64.1) | 62.1 (58.9, 65.3) |
| Gail 5-year risk score, % | |||||
| < 1c | 53.2 (50.2, 55.2) | 52.9 (50.4, 55.4) | 54.7 (52.2, 57.2) | 54.3 (51.8, 56.8) | 55.9 (53.4, 58.3) |
| ≥ 1c | 56.6 (53.7, 59.5) | 58.2 (55.3, 61.0) | 59.1 (56.3, 62.0) | 57.4 (54.3, 60.5) | 59.2 (56.3, 62.1) |
| Estrogen receptor status | |||||
| ER-positive | 56.1 (53.8, 58.4) | 56.4 (54.1, 58.8) | 58.9 (56.2, 61.6) | 57.2 (54.9, 59.5) | 59.2 (56.3, 62.0) |
| ER-negative | 55.8 (51.1, 60.5) | 56.8 (52.1, 61.5) | 58.0 (53.3, 62.7) | 57.1 (52.4, 61.8) | 57.1 (52.3, 61.8) |
| Number of first-degree family members with breast cancer, n (%) | |||||
| 0 | 52.2 (50.0, 54.3) | 52.8 (50.6, 55.0) | 55.6 (52.9, 58.3) | 54.6 (52.4, 56.8) | 56.8 (54.6, 58.9) |
| ≥ 1 | 55.9 (52.1, 59.6) | 55.0 (51.3, 58.7) | 57.2 (53.4, 60.9) | 56.4 (52.7, 60.1) | 57.2 (52.0, 62.4) |
aEstimates from the model as implemented in BCRAT and using BCRAT regression coefficients
bModel including Gail model variables and biomarker(s) and using regression coefficients in Table 2
cMedian 5-year absolute risk was approximately 1%