Table 3.
Top 5 up-regulated SDE genes associated with the transcription regulator activity in virus-infected cells
| Time (hpi) | Gene symbol | Gene description | rSS1GFP | rSS1GFP-M/NLSm | Molecular function | ||
|---|---|---|---|---|---|---|---|
| FCa | P value | FC | P value | ||||
| 6 | ZEB2 | Zinc finger E-box binding homeobox 2 | 6.5 | 1.21E−05 | 1.2 | 2.30E−02 | Transcriptional repressor activity |
| RARA | Retinoic acid receptor alpha | 5.3 | 6.40E−06 | 0.8 | 1.12E−03 | Transcription corepressor activity | |
| PROX1 | Prospero homeobox 1 | 3.2 | 4.00E−04 | 0.4 | 1.51E−02 | Negative regulation of transcription | |
| 12 | AHRR | Aryl hydrocarbon receptor repressor | 10.2 | 4.21E−08 | 2.3 | 3.32E−03 | Protein heterodimerization activity |
| ETS2 | ETS proto-oncogene 2 | 8.4 | 3.82E−07 | 1.4 | 2.12E−02 | Transcription repressor activity | |
| KLF11 | Kruppel like factor 11 | 7.6 | 1.09E−07 | 3.6 | 5.16E−04 | Negative regulation of transcription | |
| HDAC9 | Histone deacetylase 9 | 7.1 | 2.67E−06 | 2.7 | 4.11E−02 | Transcription corepressor activity | |
| SAMD4A | Sterile alpha motif domain containing 4A | 5.8 | 3.23E−06 | 0.6 | 1.15E−02 | Transcription repressor activity | |
| 18 | PROX1 | Prospero homeobox 1 | 9.6 | 4.12E−07 | 2.2 | 5.43E−03 | Negative regulation of transcription |
| PAIP2 | Poly(A) binding protein interacting protein 2 | 8.3 | 2.54E−05 | 1.8 | 2.80E−02 | Transcription repressor activity | |
| ETV3 | ETS variant 3 | 6.4 | 3.81E−06 | 3.1 | 4.78E−04 | Repressing transcription factor binding | |
| RUNX2 | Runt related transcription factor 2 | 6.2 | 2.41E−03 | 1.4 | 3.05E−03 | Transcription corepressor activity | |
| CCAR1 | Cell division cycle and apoptosis regulator 1 | 5.8 | 1.22E−04 | 2.0 | 1.63E−02 | Transcription corepressor activity | |
aFC: fold change in expression levels relative to those of uninfected cells. Only three SDE genes were found in rSS1GFP -infected cells at 6 hpi.