Table 2.
Pooled sensitivity and specificity of TB-LAMP
| Reference Standard | Pooled Sensitivity | Pooled Specificity |
|---|---|---|
| TB-LAMP accuracy if used as an alternative test for smear microscopy in all adults | ||
| Standard 1a | 77·7 (71·2–83·0) | 98·1 (95·7–99·2) |
| Standard 2a | 76·0 (69·9–81·2) | 98·0 (96·0–99·0) |
| Standard 3a | 80·3 (70·3–87·5) | 97·7 (96·1–98·7) |
| TB-LAMP accuracy if used as an alternative test for smear microscopy in HIV-positive adults | ||
| Standard 1a | N/A (< 4 studies) | N/A (< 4 studies) |
| Standard 2a | 63·8 (49·0–76.4) | 98·8 (85·1–99·9) |
| Standard 3a | 73·4 (51·9–87·6) | 95·0 (64·0–99·5) |
| TB-LAMP accuracy if used as an add-on test in smear-negative adults | ||
| Standard 1a | 42·1 (30·0–55·3) | 98·4 (95·9–99·4) |
| Standard 2a | 42·2 (27·9–57·9) | 98·0 (96·0–99·0) |
| Standard 3a | 40·3 (27·9–54·0) | 97·7 (96·1–98·6) |
| TB-LAMP accuracy in studies comparing to Xpertb | ||
| Standard 1a | 78·0 (66·6–86·4) | 98·9 (97·4–99·6) |
| Standard 2a | 74·1 (64·1–82·2) | 98·8 (96·8–99·6) |
| Standard 3a | 75·8 (63·2–85·0) | 98·2 (96·0–99·2) |
| Xpert accuracy in studies comparing to TB-LAMPb | ||
| Standard 1a | 81·1 (70·6–88·5) | 98·2 (95·9–99·2) |
| Standard 2a | 80·4 (73·4–85·9) | 97·4 (94·9–98·7) |
| Standard 3a | 84·0 (75·6–90·0) | 97·2 (94·4–98·6) |
aAll reference standards classify patients as having TB if ≥1 positive culture was confirmed as M. tuberculosis by speciation testing. To be classified as not having TB, patients were required to have no positive and at least 1) two negative cultures on two different sputum specimens (Standard 1); 2) two negative cultures on the same or different sputum specimens (Standard 2); or 3) at least one negative culture (Standard 3)
bData restricted to study participants who had valid results for both TB-LAMP and Xpert and testing performed on non-frozen specimens
Abbreviations: N/A not applicable