Table 3.

TB-LAMP versus Xpert: Pooled Sensitivity and Specificity differences

Reference standard	Pooled sensitivity differenceb	Pooled specificity differenceb
Standard 1a	-2·5 (− 8·0 to + 2·9)	0·5 (− 0·9 to + 1·8)
Standard 2a	− 6·0 (− 12·1 to + 0·1)	1·0 (− 0·3 to + 2·4)
Standard 3a	− 6·9 (− 12·8 to − 1·0)	1·1 (− 0·7 to + 2·8)

^aAll reference standards classify patients as having TB if ≥1 positive culture was confirmed as M. tuberculosis by speciation testing. To be classified as not having TB, patients were required to have no positive and at least 1) two negative cultures on two different sputum specimens (Standard 1); 2) two negative cultures on the same or different sputum specimens (Standard 2); or 3) at least one negative culture (Standard 3)

^bPositive difference favors TB-LAMP