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Generation of cGMP in human renal proximal tubular epithelial cells (HRPTCs) and human aortic endothelial cells (HAECs) stimulated by BNP, URO, and CRRL269. Three doses including 10−9, 10−8, and 10−7 M were used. *P < 0.05 vs. negative control, †P < 0.05 vs. BNP, #P < 0.05 vs. URO.
