Fig. 4.

Urinary flow (UV) (A) and urinary sodium excretion (UNaV) (B) after infusion of low- 2 pmol·kg⁻¹·min⁻¹ and high-dose 33 pmol·kg⁻¹·min⁻¹ BNP, URO, or CRRL269 in normal canines. Data are calculated from the difference from baseline. BL, baseline; Low, infusion of low-dose 2 pmol·kg⁻¹·min⁻¹ BNP, URO, or CRRL269; High, infusion of high-dose 33 pmol·kg⁻¹·min⁻¹; Wo, washout (0–30 min postinfusion); Rec 1, recovery 1, 30–60 min postinfusion; Rec 2, recovery 2, 60–90 min postinfusion. *P < 0.05 vs. baseline (one-way ANOVA and Dunnett posttests), †P < 0.05 vs. BNP, #P < 0.05 vs. URO (two-way ANOVA and Bonferroni post hoc tests).