Table 2.
Association between maternal urine cotinine in early pregnancy and children’s neurodevelopment at 24 months
| Cotinine | Bayley | n | Mean ± SD | Unadjusteda | Adjustedb | ||||
|---|---|---|---|---|---|---|---|---|---|
| β | 95% C.I. | P | β | 95% C.I. | P | ||||
| ≤ 1.90 | MDI | 368 | 97.05 ± 14.81 | 1.41 | (−1.57, 4.38) | 0.35 | 1.31 | (−1.52, 4.14) | 0.36 |
| PDI | 368 | 96.86 ± 14.07 | 1.63 | (−1.20, 4.46) | 0.26 | 1.88 | (−0.90, 4.66) | 0.19 | |
| > 1.90 | MDI | 352 | 96.97 ± 14.24 | −1.79 | (−4.29, −0.71) | 0.16 | −2.73 | (−5.32, − 0.15) | 0.04 |
| PDI | 352 | 96.70 ± 12.89 | −0.60 | (−2.87, 1.67) | 0.61 | − 0.35 | (−2.69, 2.00) | 0.77 | |
aGeneral Linear Model adjusted for creatinine
bGeneral Linear Model adjusted for maternal age, maternal education, gestational age, infant sex, region, breastfeeding behavior, primary caregiver, and creatinine
MDI Mental Development Index, PDI Psychomotor Development Index