Fig. 6.

Baseline mean arterial pressure (AP) and phenylephrine (PE)-induced bradycardia in untreated and metformin-treated lean Zucker rats (LZR) and obese Zucker rats (OZR). A: mean AP in untreated and metformin-treated, conscious LZR and OZR. See Table 3 for more baseline values. Data were analyzed by ANOVA with Tukey’s honestly significant difference (HSD) tests. *P < 0.05 vs. like-treated LZR and †P < 0.05 vs. untreated OZR. B: representative tracing from an untreated LZR illustrating baseline period for MAP and period of analysis for PE-induced decrease in heart rate (HR). C: PE-induced decrease in HR in untreated and metformin-treated LZR and OZR. Data were analyzed by ANOVA with Tukey’s HSD tests. *P < 0.05 vs. like-treated LZR and †P < 0.05 vs. untreated OZR.