Table 2.
Glucose tolerance test in 15- to 17-wk-old LZR and OZR
| Group | n | Age, days | Body Weight, g | Time to Peak, min | AUC, mg/dl × 3 h |
|---|---|---|---|---|---|
| Untreated | |||||
| LZR | 5 | 108.2 ± 0.2 | 351.4 ± 10.5 | 21.0 ± 1.0 | 310.8 ± 80.6 |
| OZR | 5 | 108.2 ± 0.2 | 552.6 ± 20.1* | 27.0 ± 2.0* | 940.6 ± 138.5* |
| Metformin-treated | |||||
| LZR | 6 | 108.0 ± 0.0 | 273.3 ± 22.0† | 19.2 ± 0.8 | 341.6 ± 66.4 |
| OZR | 6 | 109.5 ± 1.5 | 500.0 ± 22.6* | 22.5 ± 1.1† | 547.7 ± 91.6† |
| P values | |||||
| Rat type | 0.383 | <0.001 | 0.002 | <0.001 | |
| Treatment | 0.520 | 0.005 | 0.023 | 0.074 | |
| Interaction | 0.383 | 0.536 | 0.308 | 0.040 |
Data are expressed as means ± SE; n, number of rats. Age and weight were determined the morning of the glucose tolerance test (Fig. 4). The area under the curve (AUC) was measured as the difference from baseline at 5-min increments from −15 to 165 min in relation to the injection of glucose. Each measure was analyzed by 2-way ANOVA for rat type × treatment followed by Tukey’s honestly significant difference tests. See Figs. 3 and 4 for blood glucose values in these rats. LZR, lean Zucker rat; OZR, obese Zucker rat.
*
P < 0.05 vs. LZR of like treatment,
†
P < 0.05 vs. untreated rat of same type.