Table 3.

Effects of metformin treatment on plasma insulin, cholesterol, and triglycerides

Group	n	Age, days	Body Weight, g	Insulin, ng/dl	Cholesterol, mg/dl	Triglycerides, mg/dl
Untreated
LZR	7	115.3 ± 1.7	351.7 ± 10.5	3.8 ± 1.3	107.5 ± 7.8	16.3 ± 2.9
OZR	6	114.0 ± 1.3	583.5 ± 28.7*	22.9 ± 0.4*	227.1 ± 16.2*	52.6 ± 16.0
Metformin
LZR	8	116.5 ± 0.3	338.1 ± 11.8	2.3 ± 0.4	124.4 ± 7.5	18.2 ± 3.0
OZR	8	113.0 ± 1.4	493.6 ± 14.2*†	18.5 ± 2.1*†	206.2 ± 17.8*	68.6 ± 18.5*
P values
Rat type		0.064	<0.001	<0.001	<0.001	0.002
Treatment		0.972	0.004	0.046	0.880	0.478
Interaction		0.364	0.029	0.312	0.166	0.574

Values are means ± SE; n, number of rats. Blood samples were collected from arterial line at ~9:00 AM in conscious rats with access to food and water before infusion of phenylephrine. Each measure was analyzed by 2-way ANOVA for rat type × treatment followed by Tukey’s honestly significant difference tests. LZR, lean Zucker rat; OZR, obese Zucker rat.

^*P < 0.05 vs. LZR of like treatment,

^†P < 0.05 vs. untreated rat of same type.