Table 1.
Clinical Characteristics of Patients Who Received NK Cell Therapy
| UPN | Characteristics at Diagnosis | HLA Status | Donor KIR– Recipient HLA Mismatch | Peak NK Cell Chimerism | Adoptive NK Cell Transfer | Days from NK cell transplant to relapse | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Age at diagnosis (Years) | Sex | Karyotype | Bw | C | % | Day | NK Cells− (106/kg) | |||
| 1 | 1.1 | M | t(11;19) | 6/6 | C1/C1 | CD158a, CD158e1 | 0 | 7 | 16.5 | – |
| 2 | 1.6 | F | + 4,t(6;11),+der(6)t(6;11),+ 8,+ 13,+ 19 | 4/6 | C2/C2 | CD158b | 1 | 14 | 11.5 | 629 |
| 3 | 2.1 | M | t(9;11),+X,+ 7,+ 8 | 4/6 | C2/C2 | CD158b | 2 | 6 | 12.4 | – |
| 4 | 10.2 | F | 46,XX | 4/6 | C2/C2 | CD158b | 4 | 12 | 8.2 | 527 |
| 5 | 1.2 | F | t(1;22),+ 2,+ 8,+ 21,+der(22)t(1;22) | 4/6 | C1/C1 | CD158a | 23 | 7 | 46.9 | 617 |
| 6 | 15.4 | F | 46,XX | 6/6 | C1/C2 | CD158e1 | 8 | 13 | 3.6 | – |
| 7 | 1.2 | F | t(11;19),t(12;19) | 4/6 | C2/C2 | CD158b | 2 | 8 | 36.9 | – |
| 8 | 0.1 | F | N/A | 6/6 | C1/C2 | CD158e1 | 43 | 14 | 44.3 | – |
| 9 | 0.5 | F | der(10) | 4/6 | C1/C1 | CD158a | 15 | 7 | 26.8 | – |
| 10 | 4.5 | M | 46,XY | 6/6 | C1/C1 | CD158a, CD158e1 | 6 | 7 | 14.8 | 300† |
| 11 | 2.1 | M | t(1;11),+ 9 | 6/6 | C1/C1 | CD158a, CD158e1 | 2 | 7 | 25.7 | – |
| 12 | 13.2 | F | + 8,t(11;19),+ 17,+ 19 | 6/6 | C1/C1 | CD158a, CD158e1 | 15 | 7 | 6.7 | 228 |
| 13 | 15.3 | F | + 21 | 4/6 | C1/C1 | CD158a | 14 | 12 | 5.2 | – |
| 14 | 12.4 | M | t(1;2),del(9),-12,t(17;20),der(18) | 4/6 | C1/C1 | CD158a | 3 | 7 | 8.8 | 186† |
| 15 | 1.6 | M | + 8,t(9;11;14) | 4/6 | C2/C2 | CD158b | 0 | 7 | 12.5 | – |
| 16 | 14.3 | F | ins(10;11),ins(17;11) | 4/6 | C1/C1 | CD158a | 22 | 7 | 5.7 | 231† |
| 17 | 0.7 | M | t(5;6) | 4/6 | C2/C2 | CD158b | 32 | 21 | 42.4 | – |
| 18 | 3.0 | M | 46,XY | 4/6 | C1/C1 | CD158a | 0 | 7 | 62.6 | – |
| 19 | 4.0 | M | 46,XY | 4/6 | C1/C1 | CD158a | 4 | 7 | 12.4 | – |
| 20 | 12.2 | M | +X,+ 9,+ 11,+ 14,+ 20 | 6/6 | C1/C2 | CD158e1 | 1 | 7 | 9.0 | 367 |
| 21 | 9.2 | M | 46,XY | 6/6 | C1/C1 | CD158a, CD158e1 | 10 | 7 | 19.3 | – |
Abbreviations: CNS central nervous system, HLA human leukocyte antigen, KIR killer immunoglobulin-like receptor, N/A not available, NK natural killer, UPN unique patient number. † Deceased