Table D.
Transcription factors and culture conditions used for hepatocyte differentiation
| Transcription factors | Growth factors | Use of serum | Additional factors | Induced factors | Reference |
|---|---|---|---|---|---|
| Sox 17, HEX, HNF4α | Activin A, BMP4, HGF | Yes | Oncostatin M, Dexamethasone, ITS | GATA6, Sox17, HNF4α | Takayama et al. [56] |
| FoxA2, GATA4, Hex, C/EBPα | EGF, BMP, bFGF, EGF, NGF, TGFβ, HGF | No | Oncostatin M, Ratinoic acid, dexamethasone, ITS (Insulin, transferrin, selenium) | Tomizawa et al. [51] | |
| N/A | BMP, Activin A, FGF2, HGF | No | Oncostatin | Si-tayeb et al. [58] | |
| N/A | Activin A, FGF-4, HGF, BMP2, BMP4, | Yes | Oncostatin, dexamethasone | Ma et al. [57] Duan et al [89] |