TABLE I.
Patient characteristics and cohort composition
| Parameter | Learning set |
Test set |
Equivocal set |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| EoE | Control | GERD | P value | EoE | Control | GERD | P value | EoE | GERD | P value | |
| No. | 38 | 49 | 26 | 22 | 30 | 15 | 8 | 5 | |||
| Age at diagnosis (y), median (range) | 10.31 (2.03–18.63) | 10.08 (1.25–18.66) | 10.79 (1.44–17.89) | .948 | 10.78 (2.42–18.38) | 10.02 (1.20–18.14) | 13.63 (1.20–18.64) | .207 | 7.32 (2.58–10.77) | 12.10 (5.53–13.8) | .052 |
| Male sex | 28/38 (74) | 18/49 (37) | 17/26 (65) | <.001 | 15/22 (68) | 14/30 (47) | 10/15 (67) | .225 | 5/8 (63) | 3/5 (60) | .929 |
| Symptoms in the past year | |||||||||||
| Dysphagia | 21/38 (55) | 12/49 (24) | 5/26 (19) | <.001 | 11/22 (50) | 9/30 (30) | 4/15 (27) | .233 | 4/8 (50) | 1/5 (20) | .279 |
| Food impaction | 12/38 (32) | 2/49 (4) | 0/26 (0) | <.001 | 5/22 (23) | 0/30 (0) | 0/15 (0) | .003 | 2/8 (25) | 0/5 (0) | .224 |
| Chest pain | 2/38 (5) | 1/49 (2) | 2/26 (8) | .502 | 2/22 (9) | 2/30 (7) | 1/15 (7) | .939 | 1/8 (13) | 0/5 (0) | .411 |
| Epigastric pain | 2/38 (5) | 13/49 (27) | 5/26 (19) | .035 | 5/22 (23) | 9/30 (30) | 1/15 (7) | .208 | 0/8 (0) | 0/5 (0) | NA |
| Reflux symptoms | 10/38 (26) | 20/49 (41) | 18/26 (69) | .003 | 10/22 (45) | 17/30 (57) | 8/15 (53) | .723 | 2/8 (25) | 0/5 (0) | .224 |
| Feeding difficulties | 5/38 (13) | 7/49 (14) | 3/26 (12) | .946 | 4/22 (18) | 6/30 (20) | 1/15 (7) | .504 | 2/8 (25) | 2/5 (40) | .569 |
| Vomiting | 5/38 (13) | 14/49 (29) | 7/26 (26) | .206 | 6/22 (27) | 5/30 (17) | 3/15 (20) | .646 | 0/8 (0) | 0/5 (0) | NA |
| Endoscopy | |||||||||||
| Pallor | 6/38 (16) | 1/49 (2) | 0/25 (0) | .010 | 1/22 (5) | 1/30 (3) | 2/15 (13) | .387 | 1/8 (13) | 0/5 (0) | .411 |
| Edema | 5/38 (13) | 1/49 (2) | 0/25 (0) | .028 | 3/22 (14) | 0/30 (0) | 0/15 (0) | .040 | 1/8 (13) | 1/5 (20) | .715 |
| Loss of vascularity | 16/38 (42) | 1/49 (2) | 5/25 (20) | <.001 | 6/22 (28) | 0/30 (0) | 2/15 (13) | .011 | 3/8 (38) | 0/5 (0) | .118 |
| Furrowing | 30/38 (79) | 3/49 (6) | 7/25 (28) | <.001 | 18/22 (82) | 2/30 (7) | 2/15 (13) | <.001 | 6/8 (75) | 3/5 (60) | .569 |
| Exudate | 15/38 (39) | 3/49 (6) | 1/25 (4) | <.001 | 7/22 (32) | 2/30 (7) | 0/15 (0) | .007 | 1/8 (13) | 1/5 (20) | .715 |
| Allergic/atopic conditions | |||||||||||
| Serum IgE levels (IU/mL), median (range) | 137 (4–1240) | 56 (7–736) | 25 (5–734) | .300 | 107 (8–744) | 37 (11–1524) | 344 (11–970) | .513 | 45 (7–2491) | 744.5 (0–1489) | .818 |
| Eczema | 10/37 (27) | 4/48 (8) | 5/26 (19) | .066 | 4/22 (18) | 4/29 (14) | 4/14 (29) | .504 | 3/6 (50) | 0/2 (0) | .206 |
| Asthma | 7/27 (19) | 3/48 (6) | 1/26 (4) | .013 | 5/22 (23) | 3/29 (10) | 4/14 (29) | .289 | 4/6 (67) | 1/2 (50) | .673 |
| Allergic rhinoconjunctivitis | 22/37 (59) | 3/48 (6) | 2/26 (8) | <.001 | 12/22 (55) | 3/29 (10) | 3/14 (21) | .002 | 3/6 (50) | 1/2 (50) | 1.000 |
| Food allergy | 11/37 (30) | 4/48 (8) | 1/26 (4) | .004 | 5/22 (23) | 5/30 (17) | 3/14 (21) | .879 | 4/6 (67) | 2/3 (67) | 1.000 |
| RAST/skin prick test | 30/36 (83) | 7/16 (44) | 4/10 (40) | .003 | 14/18 (78) | 4/11 (36) | 5/8 (63) | .083 | 5/7 (71) | 1/2 (50) | .571 |
| Esophageal eosinophils | |||||||||||
| Maximum, median (range) | 47.5 (15–120) | 0 (0–0) | 2 (0–14) | <.001 | 50 (15–150) | 0 (0–0) | 1 (0–8) | <.001 | 40 (12–120) | 20 (0–50) | .134 |
Values are n/n (%) unless otherwise indicated. P values calculated by chi-squared test.