Figure 1.

Ortholog database coverage for fungal and yeast genomes in AYbRAH, YGOB, CGOB, PANTHER, HOGENOM, KO, OMA and eggNOG. Ortholog assignments based on the manual curation of sequence similarity and synteny are shown in green columns, tree-based methods in red columns, graph-based methods in blue columns and a hybrid graph and tree-based method in the purple column. Many ortholog databases are well represented in Saccharomycetaceae and the CTG clade, which had their genomes sequenced during the 2000s (26). AYbRAH has ortholog assignments for species in Pichiaceae, Phaffomycetaceae and several incertae sedis families, which are not well represented in other ortholog databases, as these yeasts were recently sequenced (28). The well established phylogenomic databases span other yeast species not shown in this phylogeny, but they mostly belong to Saccharomycetaceae or the CTG clade.