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Example of over-clustering by OrthoMCL with the hexokinase family and its curation in AYbRAH. A gene duplication of HXK2 in Pichiaceae led to the HXK3 paralog. HXK2 was subsequently lost in Ogataea parapolymorpha but maintained in Komagataella phaffii. OrthoMCL was unable to differentiate between the Hxk2p and Hxk3p orthologs. Both ortholog groups are also assigned to the same Fungi-level ortholog group in OrthoDB.
