Table 1.
Study characteristics by first-degree relative status
| Variable | FDR children (n = 423) | GP children (n = 4,149) |
|---|---|---|
| Males | 200 (47.3) | 2,082 (50.2) |
| HLA genotype | ||
| DR3/4-DQ8 | 280 (66.2) | 2,755 (66.4) |
| DR4-DQ8/DR4-DQ8 | 143 (33.8) | 1,394 (33.6) |
| Country | ||
| U.S. | 194 (45.9) | 1,750 (42.2) |
| Finland | 51 (12.1) | 792 (19.1) |
| Germany | 92 (21.7) | 209 (5.0) |
| Sweden | 86 (20.3) | 1,398 (33.7) |
| First-degree relative with T1D | ||
| None | 0 (0.0) | 4,149 (100.0) |
| Mother | 146 (34.5) | 0 (0.0) |
| Father | 180 (42.6) | 0 (0.0) |
| Sibling | 79 (18.7) | 0 (0.0) |
| Multiplex | 18 (4.3) | 0 (0.0) |
| Outcome events | ||
| One or more islet autoantibodies | 85 (20.1) | 415 (10.0) |
| Multiple islet autoantibodies | 69 (16.3) | 255 (6.1) |
| First-appearing IAA | 51 (12.1) | 227 (5.5) |
| First-appearing GADA | 46 (10.9) | 250 (6.0) |
| Diabetes | 47 (11.1) | 145 (3.5) |
| Genetic risk score available | 408 (96.5) | 4,006 (96.6) |
Data are n (%).