Table 3.
Cox proportional hazards models for developing islet autoantibodies and diabetes in FDR children compared with GP children (reference)
| One or more islet autoantibodies |
Multiple islet autoantibodies |
Diabetes |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Model 1* |
Model 2* |
Model 1* |
Model 2* |
Model 1* |
Model 2* |
|||||||
| HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
| FDR child | 2.12 (1.65–2.72) | <0.0001 | 1.82 (1.42–2.35) | <0.0001 | 2.77 (2.09–3.68) | <0.0001 | 2.26 (1.70–3.02) | <0.0001 | 3.69 (2.60–5.23) | <0.0001 | 2.92 (2.05–4.16) | <0.0001 |
| DRB1*04:01/x† | 1.42 (1.10–1.83) | 0.0075 | 1.48 (1.08–2.01) | 0.014 | 1.38 (0.93–2.04) | 0.1052 | ||||||
| Genetic risk score‡ | 1.48 (1.34–1.64) | <0.0001 | 1.66 (1.47–1.88) | <0.0001 | 1.67 (1.42–1.96) | <0.0001 | ||||||
| BTNL2 rs3763305 GG§ | 1.05 (0.79–1.40) | 0.73 | 1.39 (0.96–2.00) | 0.080 | 1.80 (1.11–2.93) | 0.0175 | ||||||
| ITGA1 rs7735139 GG§ | 1.18 (0.86–1.63) | 0.30 | 1.06 (0.70–1.60) | 0.77 | 1.11 (0.67–1.87) | 0.6776 | ||||||
*Model 1 and 2 are adjusted for sex, country (reference: U.S.), and HLA genotype (reference: DR4-DQ8/DR4-DQ8).
†Reference: DRB1 without 04:01 or 04:01/04:04 and 04:01/04:07.
‡Per unit increase.
§Reference: GA/AA genotype.