Table 4.
BTNL2 SNP genotype frequencies in relation to the development of islet autoantibodies and diabetes among TEDDY children with HLA DR3/DR4-DQ8 or DR4-DQ8/DR4-DQ8 and available genotype information
| Islet autoantibody negative | One or more islet autoantibodies | Multiple islet autoantibodies | Diabetes | |
|---|---|---|---|---|
| HLA DR3/4-DQ8 (n = 3,024), BTNL2 SNP rs3763305 | ||||
| GG | 1,839 (69.1) | 272 (75.3) | 190 (79.8) | 120 (82.8) |
| GA | 823 (30.9) | 89 (24.7) | 48 (20.2) | 25 (17.2) |
| AA | 1 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
| P* | 0.030 | 0.0007 | 0.0007 | |
| HLA DR4-DQ8/DR4-DQ8 (n = 1,532), BTNL2 SNP rs3763305 | ||||
| GG | 692 (49.7) | 89 (64.0) | 63 (73.3) | 36 (76.6) |
| GA | 571 (41.0) | 44 (31.7) | 21 (24.4) | 10 (21.3) |
| AA | 130 (9.3) | 6 (4.3) | 2 (2.3) | 1 (2.1) |
| P* | 0.0033 | <0.0001 | 0.0010 |
Data are n (%).
*Children who remained islet autoantibody negative were compared with children who developed one or more islet autoantibodies, multiple islet autoantibodies, and diabetes using Fisher test.