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GRP94 KO and GRP94 ATPase inhibition lead to diminished content of mature insulin in secretory granules
| Number of insulin molecules detected | Control | GRP94i | GRP94 KO |
|---|---|---|---|
| 0 | 68 | 84 | 78.5 |
| 1–2 | 22 | 10 | 15.5 |
| 3–4 | 9.7 | 5.4 | 5.8 |
| 5 and more | 11.7 | 8.4 | 5.5 |
Data represent the percentage of each category of stained vesicles vs. all vesicles counted in a given experimental condition.
