Table II.
Comparison of study medication period duration, sampling times and compliance between the 20 mg BD and 75 mg OD aspirin regimens. Values are shown as mean ± SD and p values were generated by paired t-tests.
| – | 20 mg BD | 75 mg OD | p value |
|---|---|---|---|
| Time from aspirin dose to post-aspirin venepuncture (mins) | 124.7 ± 18.2 | 123.1 ± 10.2 | 0.68 |
| Time from last ticagrelor dose to pre-aspirin venepuncture (mins) | 214.0 ± 208.5 | 184.9 ± 160.2 | 0.36 |
| Time from aspirin dose to bleeding time measurement (mins) | 122.2 ± 21.0 | 122.8 ± 19.6 | 0.88 |
| Time from last aspirin dose to collection of urine sample (mins) | 133.9 ± 24.7 | 136.2 ± 24.6 | 0.76 |
| Time of aspirin dose on day of sampling from previous dose (hrs) | 13.7 ± 2.4 | 26.2 ± 1.8 | NA |
| Compliance with aspirin therapy (% of doses taken) | 99.9 ± 0.7 | 100.0 ± 0.0 | 0.33 |
| Compliance with ticagrelor therapy (% of doses taken) | 100.0 ± 0.0 | 99.7 ± 1.3 | 0.33 |
| Time on study medication (days) | 14.95 ± 2.0 | 14.80 ± 1.47 | 0.55 |
| Systolic BP (mmHg) | 127.3 ± 12.9 | 128.8 ± 15.5 | 0.67 |
| Diastolic BP (mmHg) | 72.2 ± 10.2 | 71.1 ± 10.2 | 0.53 |
| Heart rate (bpm) | 60.7 ± 6.0 | 62.3 ± 10.3 | 0.49 |
BD, twice daily; BP, blood pressure; bpm, beats per minute; hrs, hours; mmHg, millimeters of mercury; Mins, minutes; NA, not applicable; OD, once daily