Table 2. Replication Cohort Sequencing Results6.
Chromosome | Position | ID | REF | ALT | MAF cases | MAF controls |
---|---|---|---|---|---|---|
22 | 33253280 | rs9862 | T | C | 50.00% | 50.00% |
22 | 33253292 | rs11547635 | C | T | 14.29% | 6.40% |
22 | 33255244 | rs149161075 | C | T | 3.57% | 0.00% |
Gene | P value | N variants in Test | ||||
TIMP3 | 0.03734* | 3 |
Variants identified in Danish cohort by Sanger sequencing of TIMP3 exons.
ID; rs identifier from dbSNP
MAF; minor allele frequency
P value; calculated by SKAT-O gene-based association test
reaches the significance threshold of <0.05
N; number