Figure 4. n‐3 PUFA supplementation delays the breathing frequency response at the onset of hypoxia.

Time course of the breathing frequency response to hypoxia (12%). Data are expressed as percentage change from baseline (normoxia) and compared between groups and sexes: males (A) and females (B) that received n ‐3 PUFA supplementation (black circles) and control (CTRL) (white circles). C, gain index of the O₂ chemoreflex calculated as the mean frequency increase observed over the 3rd and 4th minute of hypoxia; this value is reported in arbitrary units reflecting the percentage change from baseline. Numbers in brackets indicate the number of replicates in each group. Data are expressed as the mean ± SEM. Post hoc pairwise comparisons were performed only when warranted by ANOVA. Significantly different from CTRL: ^* P ≤ 0.05.