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Cyclic mechanical strain of bone marrow-derived macrophages. Macrophages were subjected to 10% mechanical strain for 5 h using the FlexCell system. Five-hour mechanical strain resulted in an F480+/iNOS−/Fizz1+ macrophage phenotype, suggesting that mechanical strain alone can promote macrophage activation toward a proremodeling phenotype. (*p < 0.05 when compared to the MCSF-unflexed group, n = 5, error bars represent standard deviation). MCSF, macrophage colony stimulating factor.
