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. 2019 Apr;25(4):431–452. doi: 10.1261/rna.068858.118

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© 2019 Sanz et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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FIGURE 10. — Schematic representation of the initiation events of SINV sgRNA. Initially, the 40S ribosomal subunit together with eIF1, eIF1A, and eIF3 interact with the cap structure at the 5′ end of sgRNA. Then, scanning of the leader sequence takes place until the AUG initiation codon is recognized. The DSH structure interacts with the 40S to stop scanning and to promote the binding of the 60S ribosomal subunit, after the dissociation of eIFs promoted by eIF5B. Once the 80S ribosome is formed, the elongation phase proceeds.