Fig. 9.

Lamin B1-DamID profile for mouse primary hepatocytes over a 1.2 Mb stretch of chromosome 1. The unsmoothed DamID profile is shown where positive values are dark blue and negative values pale blue. LADs calculated using CBS without smoothing (sm = 0) misses the smaller LADs and has in general a coarser level of resolution. Using a smoothing level of 20 (sm = 20) easily detects the smaller LADs that would otherwise be ignored. The bottom panel displays the segmentation produced by CBS using various levels of smoothing. Orange segments represent positive LaminB1 associations (LADs), and dark grey negative ones (interLADs), with white being neutral. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)