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Oxidative stress expressed by plasma levels of malondialdehyde (MDA) upon the first and second endotoxin challenge. MDA concentrations over time are depicted as mean and sem. The inserts depict the individual area under the time concentration curves (AUC) data expressed as nmol × hr/mL. The gray area indicates the 3-hr endotoxin administration period. p values represent the interaction term of repeated measures two-way analysis of variance. ASA = acetylsalicylic acid.
