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. 2019 Mar 18;12(3):e007071. doi: 10.1161/CIRCEP.118.007071

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© 2019 The Authors.

Circulation: Arrhythmia and Electrophysiology is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 8. — Valproic acid (VPA) counteracts protein deregulation in CREM-IbΔC-X transgenic (TG) mice atria. 60 of the 295 selected proteins (compare Figure 7C) were strongest counter-regulated by VPA (n=5–8/treatment group). Each row corresponds to the protein stated on the right. Colors: relative protein levels (blue=minimum; red=maximum). Proteins are grouped according to their assigned pathways. *Proteins already regulated at 7 wk in TG_VEH vs WT_VEH.¹⁰ †Proteins encoded by CREM-target genes (compare chromatin immunoprecipitation analysis Table III in the Data Supplement). CREM-IbΔC-X indicates CREM (cAMP responsive element modulator) isoform IbΔC-X.