Table 1.

Summary of pathological and problem patients treated with naltrexone for whom there existed a full complement of follow-up materials

	Age, Sex	Referral route	Gambling career (years)	ETL	PGSI (/27)	Medical comorbidities	Psychiatric comorbidities	Other addictive pathologies	Reported medications	Social history	Forensic history	Treatment goal	Pre-treatment GCS (/30)	Post-treatment GCS (/30)	Naltrexone side effects	Reported gambling activity
1	43, M	GP	17	£1,700,000	27	Hypercholesterolerria Angina	Schizophrenia	History of cocaine abuse	Risperidone 4 mg	Divorced, lives alone, three children (no contact), unemployed, reported domestic violence, and poor relationship with family	Six custodial sentences related to gambling, longest 6 years	Abstinence	30	9	None	Gambled a small ticket on two occasions in the first 3 weeks Abstained from the fourth week of treatment
						Recurrent urinary tract Lipomas			Citalopram 20 mg
									Atorvastatin 20 mg
2	56, F	Psychiatrist	3	£5,000	19	Raised alanine transaminase and night seizures	Bipolar affective disorder	None reported	Aripiprazole 20 mg	Lives with daughter (30), physically abused by mother, and raped by brother at 13	None reported	Reduction	28	6	Loss of appetite	One episode of PG in 7 weeks. Now does the Euromillions once a week – £9, which was her treatment goal
3	29, M	Past patient	5	£100,000	21	None reported	None reported	None reported	None reported	Weekly binge drinking and cocaine use	Stealing to fund gambling	Reduction	7	4	Stomach pains	None
4	45, M	Self-referral	25	None reported	23	None reported	None reported	Alcohol and cocaine	None reported	Use of MDMA, family history of gambling, brother PG, and facial disfigurement	None reported	Abstinence	27	3	Evening tiredness	None during treatment period. Report of relapse afterward
5	47, F	Past patient	30	£10,000	22	Osteoarthritis, hypertension, and Crohn’s disease	Depression and obsessive and compulsive traits	None reported	Sertraline 150 mg	Spent time in care as child, father PG and alcoholic, unemployed, with adult children	None reported	Abstinence	30	7	Rapid pulse first few days	None
6	37, M	From inpatient unit	25	£1,000,000	14	None reported	Obsessive compulsive traits	None reported	None reported	No significant family history, having young children	Under investigation for missing stock at work	Abstinence	28	5	Stomach pains, dizziness, nausea, and headaches for the first few days	None
7	54, M	Self-referral	40	£300,000	12	Hypertension	Attention-deficit hyperactivity disorder	Pomography, shopping, and eating	Citalopram 30 mg	Divorced, taxi driving creates temptation, having two young children	None reported	Abstinence	27	13	Nausea for the first few days	None
8	31, M	Self-referral	15	£60,000	27	None reported	Anxiety and depression	None reported	None reported	Heavy social drinking housed by social services, three children by two mothers, and umemployed	None reported	Abstinence	7	0	None	None
9	47, M	Self-referral	30	£500,000	23	None reported	Depression	Alcohol	Citalopram 20 mg	Two brothers with drug addictions, single and living alone, beaten by father as child	Significant forensic history	Abstinence	27	17	Stomach cramps, vivid deams, headaches	Relapse – had a relapse of his alcoholism and failed to take the naltrexone
10	34, M	GP	14	None reported	12	None reported	Depression	Alcohol, heroin, tramadol, and codeine		Single, in care as a child, previously homelessness, and unemployed	None reported	Abstinence	25	3	Reduced appetitie, and feeling “spaced out”	Relapse – intrusive side effects and could not forsake heavy drinking Advised to stop taking the naltrexone as a result

Note. ETL: estimated total loss; PGSI: Problem Gambling Severity Index; GP: general practitioner.